2ki9: Difference between revisions

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{{Seed}}
[[Image:2ki9.jpg|left|200px]]


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==Human cannabinoid receptor-2 helix 6==
The line below this paragraph, containing "STRUCTURE_2ki9", creates the "Structure Box" on the page.
<StructureSection load='2ki9' size='340' side='right'caption='[[2ki9]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ki9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KI9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ki9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ki9 OCA], [https://pdbe.org/2ki9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ki9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ki9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ki9 ProSAT]</span></td></tr>
{{STRUCTURE_2ki9|  PDB=2ki9  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNR2_HUMAN CNR2_HUMAN] Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.<ref>PMID:10051546</ref> <ref>PMID:12663043</ref> <ref>PMID:12711605</ref> <ref>PMID:18692962</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We detail the structure and dynamics of a synthetic peptide corresponding to transmembrane helix 6 (TMH6) of human cannabinoid receptor-2 (hCB2) in biomembrane-mimetic environments. The peptide's NMR structural biology is characterized by two alpha-helical domains bridged by a flexible, nonhelical hinge region containing a highly-conserved CWFP motif with an environmentally sensitive, Pro-based conformational switch. Buried within the peptide's flexible region, W(258) may hydrogen-bond with L(255) to help stabilize the Pro-kinked hCB2 TMH6 structure and position C(257) advantageously for interaction with agonist ligands. These characteristics of hCB2 TMH6 are potential structural features of ligand-induced hCB2 activation in vivo.


===Human cannabinoid receptor-2 helix 6===
Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.,Tiburu EK, Tyukhtenko S, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A Biochem Biophys Res Commun. 2009 Jun 26;384(2):243-8. Epub 2009 May 3. PMID:19397896<ref>PMID:19397896</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19397896}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2ki9" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19397896 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19397896}}
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</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
2KI9 is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KI9 OCA].
[[Category: Large Structures]]
 
[[Category: Deshmukh L]]
==Reference==
[[Category: Janero DR]]
<ref group="xtra">PMID:19397896</ref><references group="xtra"/>
[[Category: Makriyannis A]]
[[Category: Deshmukh, L.]]
[[Category: Tiburu EK]]
[[Category: Janero, D R.]]
[[Category: Tyukhtenko S]]
[[Category: Makriyannis, A.]]
[[Category: Vinogradova O]]
[[Category: Tiburu, E K.]]
[[Category: Tyukhtenko, S.]]
[[Category: Vinogradova, O.]]
[[Category: G-protein coupled receptor]]
[[Category: Gpcr]]
[[Category: Human cannabinoid receptor-2]]
[[Category: Membrane protein]]
 
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Retrieved from "https://proteopedia.org/2ki9"