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New page: left|200px<br /><applet load="1ic0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ic0, resolution 2.10Å" /> '''RED COPPER PROTEIN N...
 
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[[Image:1ic0.gif|left|200px]]<br /><applet load="1ic0" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ic0, resolution 2.10&Aring;" />
'''RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA'''<br />


==Overview==
==RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA==
Nitrosocyanin (NC) is a mononuclear red copper protein isolated from the, ammonia oxidizing bacterium Nitrosomonas europaea. Although NC exhibits, some sequence homology to classic blue copper proteins, its spectroscopic, and electrochemical properties are drastically different. The 1.65 A, resolution crystal structure of oxidized NC reveals an unprecedented, trimer of single domain cupredoxins. Each copper center is partially, covered by an unusual extended beta-hairpin structure from an adjacent, monomer. The copper ion is coordinated by His 98, His 103, Cys 95, a, single side chain oxygen of Glu 60, and a solvent molecule. In the 2.3 A, resolution structure of reduced NC, His 98 shifts away from the copper, ion, and the solvent molecule is not observed. The arrangement of these, ligands renders the coordination geometry of the NC red copper center, distinct from that of blue copper centers. In particular, the red copper, center has a higher coordination number and lacks the long Cu-S(Met) and, short Cu-S(Cys) bond distances characteristic of blue copper. Moreover, the red copper center is square pyramidal whereas blue copper is typically, distorted tetrahedral. Analysis of the NC structure provides insight into, possible functions of this new type of biological copper center.
<StructureSection load='1ic0' size='340' side='right'caption='[[1ic0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ic0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IC0 FirstGlance]. <br>
1IC0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea] with CU as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IC0 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ic0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic0 OCA], [https://pdbe.org/1ic0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ic0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ic0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic0 ProSAT]</span></td></tr>
Crystal structure of a novel red copper protein from Nitrosomonas europaea., Lieberman RL, Arciero DM, Hooper AB, Rosenzweig AC, Biochemistry. 2001 May 15;40(19):5674-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11341832 11341832]
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q820S6_NITEU Q820S6_NITEU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/1ic0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ic0 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Nitrosomonas europaea]]
[[Category: Nitrosomonas europaea]]
[[Category: Single protein]]
[[Category: Arciero DM]]
[[Category: Arciero, D.M.]]
[[Category: Hooper AB]]
[[Category: Hooper, A.B.]]
[[Category: Lieberman RL]]
[[Category: Lieberman, R.L.]]
[[Category: Rosenzweig AC]]
[[Category: Rosenzweig, A.C.]]
[[Category: CU]]
[[Category: beta hairpin]]
[[Category: cu-mad]]
[[Category: cupredoxin]]
[[Category: nitrosocyanin]]
[[Category: nitrosomonas europaea]]
[[Category: red copper]]
 
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