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New page: left|200px<br /><applet load="115d" size="450" color="white" frame="true" align="right" spinBox="true" caption="115d, resolution 1.700Å" /> '''ORDERED WATER STRUC...
 
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[[Image:115d.gif|left|200px]]<br /><applet load="115d" size="450" color="white" frame="true" align="right" spinBox="true"
caption="115d, resolution 1.700&Aring;" />
'''ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION'''<br />


==Overview==
==ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION==
The crystal structure of the deoxyoctamer d(G-G-Br U-A-BrU-A-C-C) was, refined to a resolution of 1.7 A using combined diffractometer and, synchrotron data. The analysis was carried out independently in two, laboratories using different procedures. Although the final results are, identical the comparison of the two approaches highlights potential, problems in the refinement of oligonucleotides when only limited data are, available. As part of the analysis the positions of 84 solvent molecules, in the asymmetric unit were established. The DNA molecule is highly, solvated, particularly the phosphate-sugar back-bone and the functional, groups of the bases. The major groove contains, in the central BrU-A-BrU-A, region, a ribbon of water molecules forming closed pentagons with shared, edges. These water molecules are linked to the base O and N atoms and to, the solvent chains connecting the O-1 phosphate oxygen atoms on each, strand. The minor groove is also extensively hydrated with a continuous, network in the central region and other networks at each end. The pattern, of hydration is briefly compared with that observed in the structure of a, B-dodecamer.
<StructureSection load='115d' size='340' side='right'caption='[[115d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[115d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=115D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=115D FirstGlance]. <br>
115D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=115D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=115d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=115d OCA], [https://pdbe.org/115d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=115d RCSB], [https://www.ebi.ac.uk/pdbsum/115d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=115d ProSAT]</span></td></tr>
Ordered water structure in an A-DNA octamer at 1.7 A resolution., Kennard O, Cruse WB, Nachman J, Prange T, Shakked Z, Rabinovich D, J Biomol Struct Dyn. 1986 Feb;3(4):623-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=3271041 3271041]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Cruse, W.B.T.]]
</StructureSection>
[[Category: Kennard, O.]]
[[Category: Large Structures]]
[[Category: Nachman, J.]]
[[Category: Cruse WBT]]
[[Category: Prange, T.]]
[[Category: Kennard O]]
[[Category: Rabinovich, D.]]
[[Category: Nachman J]]
[[Category: Shakked, Z.]]
[[Category: Prange T]]
[[Category: a-dna]]
[[Category: Rabinovich D]]
[[Category: double helix]]
[[Category: Shakked Z]]
[[Category: modified]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 21:46:12 2007''

Latest revision as of 06:24, 7 February 2024

ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION

115d, resolution 1.70Å

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