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New page: left|200px<br /><applet load="1ih1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ih1, resolution 2.0Å" /> '''Crystal Structure of ...
 
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[[Image:1ih1.gif|left|200px]]<br /><applet load="1ih1" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ih1, resolution 2.0&Aring;" />
'''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''<br />


==Overview==
==Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms==
The transition between B- and A-DNA was first observed nearly 50 years, ago. We have now mapped this transformation through a set of, single-crystal structures of the sequence d(GGCGCC)2, with various, intermediates being trapped by methylating or brominating the cytosine, bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary, B-nucleotides serving as a distinct transition intermediate. The details, of each step in the conversion of B- to A-DNA are thus revealed at the, atomic level, placing intermediates for this and other sequences in the, context of a common pathway.
<StructureSection load='1ih1' size='340' side='right'caption='[[1ih1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ih1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IH1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ih1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih1 OCA], [https://pdbe.org/1ih1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ih1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ih1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ih1 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.


==About this Structure==
A crystallographic map of the transition from B-DNA to A-DNA.,Vargason JM, Henderson K, Ho PS Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969<ref>PMID:11390969</ref>
1IH1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and NCO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IH1 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11390969 11390969]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1ih1" style="background-color:#fffaf0;"></div>
[[Category: Henderson, K.]]
== References ==
[[Category: Ho, P.S.]]
<references/>
[[Category: Vargason, J.M.]]
__TOC__
[[Category: MG]]
</StructureSection>
[[Category: NCO]]
[[Category: Large Structures]]
[[Category: b to a dna transition]]
[[Category: Henderson K]]
[[Category: dna transition]]
[[Category: Ho PS]]
[[Category: structural transition]]
[[Category: Vargason JM]]
 
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