3fwa: Difference between revisions

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{{Seed}}
[[Image:3fwa.jpg|left|200px]]


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==Structure of berberine bridge enzyme, C166A variant in complex with (S)-reticuline==
The line below this paragraph, containing "STRUCTURE_3fwa", creates the "Structure Box" on the page.
<StructureSection load='3fwa' size='340' side='right'caption='[[3fwa]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fwa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eschscholzia_californica Eschscholzia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.496&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=REN:(S)-RETICULINE'>REN</scene></td></tr>
{{STRUCTURE_3fwa| PDB=3fwa |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwa OCA], [https://pdbe.org/3fwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwa RCSB], [https://www.ebi.ac.uk/pdbsum/3fwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RETO_ESCCA RETO_ESCCA] Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fwa ConSurf].
<div style="clear:both"></div>


===Structure of berberine bridge enzyme, C166A variant in complex with (S)-reticuline===
==See Also==
 
*[[Reticuline oxidase|Reticuline oxidase]]
 
__TOC__
==About this Structure==
</StructureSection>
3FWA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Eschscholzia_californica Eschscholzia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWA OCA].
[[Category: Eschscholzia californica]]
[[Category: Eschscholzia californica]]
[[Category: Reticuline oxidase]]
[[Category: Large Structures]]
[[Category: Gruber, K.]]
[[Category: Gruber K]]
[[Category: Macheroux, P.]]
[[Category: Macheroux P]]
[[Category: Winkler, A.]]
[[Category: Winkler A]]
[[Category: Alakloid biosynthesis]]
[[Category: Alkaloid metabolism]]
[[Category: Bi-covalent flavinylation]]
[[Category: Cytoplasmic vesicle]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Glycoprotein]]
[[Category: N-glycosylation]]
[[Category: Oxidoreductase]]
 
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