1ihm: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /><applet load="1ihm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ihm, resolution 3.4Å" /> '''CRYSTAL STRUCTURE ANA...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(16 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1ihm.gif|left|200px]]<br /><applet load="1ihm" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ihm, resolution 3.4&Aring;" />
'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''<br />


==Overview==
==CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID==
Norwalk virus, a noncultivatable human calicivirus, is the major cause of, epidemic gastroenteritis in humans. The first x-ray structure of a, calicivirus capsid, which consists of 180 copies of a single protein, has, been determined by phase extension from a low-resolution electron, microscopy structure. The capsid protein has a protruding (P) domain, connected by a flexible hinge to a shell (S) domain that has a classical, eight-stranded beta-sandwich motif. The structure of the P domain is, unlike that of any other viral protein with a subdomain exhibiting a fold, similar to that of the second domain in the eukaryotic translation, elongation factor-Tu. This subdomain, located at the exterior of the, capsid, has the largest sequence variation among Norwalk-like human, caliciviruses and is likely to contain the determinants of strain, specificity and cell binding.
<StructureSection load='1ihm' size='340' side='right'caption='[[1ihm]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ihm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IHM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ihm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihm OCA], [https://pdbe.org/1ihm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ihm RCSB], [https://www.ebi.ac.uk/pdbsum/1ihm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ihm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_NVN68 CAPSD_NVN68] Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells.<ref>PMID:16840313</ref>  Soluble capsid protein may play a role in viral immunoevasion.<ref>PMID:16840313</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/1ihm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ihm ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1IHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 
== References ==
==Reference==
<references/>
X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10514371 10514371]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Norwalk virus]]
[[Category: Norwalk virus]]
[[Category: Single protein]]
[[Category: Bella J]]
[[Category: Bella, J.]]
[[Category: Dokland T]]
[[Category: Dokland, T.]]
[[Category: Estes MK]]
[[Category: Estes, M.K.]]
[[Category: Hardy ME]]
[[Category: Hardy, M.E.]]
[[Category: Prasad BV]]
[[Category: Prasad, B.V.]]
[[Category: Rossmann MG]]
[[Category: Rossmann, M.G.]]
[[Category: beta-barrel]]
[[Category: ef-tu-like domain caliciviridae]]
[[Category: icosahedral virus]]
[[Category: t=3 icosahedral capsid]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:02:09 2007''

Latest revision as of 06:02, 3 April 2024

CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID

1ihm, resolution 3.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1ihm&oldid=4117859"