177d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /><applet load="177d" size="450" color="white" frame="true" align="right" spinBox="true" caption="177d" /> '''SOLUTION STRUCTURE AND HYDRATION PATTERNS OF...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:177d.jpg|left|200px]]<br /><applet load="177d" size="450" color="white" frame="true" align="right" spinBox="true"
caption="177d" />
'''SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE'''<br />


==Overview==
==SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE==
The solution structure of a pyrimidine.purine.pyrimidine DNA triplex, containing a novel T.CG base-triple has been determined via two and, three-dimensional NMR spectroscopy and restrained molecular dynamics, simulations incorporating explicit solvent and counter-ions. The T.CG, triple, which expands the triplex code, is stabilized by a single hydrogen, bond between the O-2 atom of thymine and the free amino proton of cytosine, in the Watson-Crick C.G base-pair. This hydrogen bonding alignment, produces large variations in helical twist at the dinucleotide steps, involving the thymine residue. Localized structural perturbations in the, purine-rich strand of the molecule are observed around the cytosine, residue in the T.CG triple. Globally, the triplex resembles the solution, structure of a previously solved pyrimidine.purine.pyrimidine DNA triplex, containing an unusual G.TA triple. Also conserved are the sites and, patterns of hydration in the two triplexes.
<StructureSection load='177d' size='340' side='right'caption='[[177d]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[177d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=177D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=177d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=177d OCA], [https://pdbe.org/177d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=177d RCSB], [https://www.ebi.ac.uk/pdbsum/177d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=177d ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple has been determined via two and three-dimensional NMR spectroscopy and restrained molecular dynamics simulations incorporating explicit solvent and counter-ions. The T.CG triple, which expands the triplex code, is stabilized by a single hydrogen bond between the O-2 atom of thymine and the free amino proton of cytosine in the Watson-Crick C.G base-pair. This hydrogen bonding alignment produces large variations in helical twist at the dinucleotide steps involving the thymine residue. Localized structural perturbations in the purine-rich strand of the molecule are observed around the cytosine residue in the T.CG triple. Globally, the triplex resembles the solution structure of a previously solved pyrimidine.purine.pyrimidine DNA triplex containing an unusual G.TA triple. Also conserved are the sites and patterns of hydration in the two triplexes.


==About this Structure==
Solution structure and hydration patterns of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple.,Radhakrishnan I, Patel DJ J Mol Biol. 1994 Aug 26;241(4):600-19. PMID:8057381<ref>PMID:8057381</ref>
177D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Solution structure and hydration patterns of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple., Radhakrishnan I, Patel DJ, J Mol Biol. 1994 Aug 26;241(4):600-19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8057381 8057381]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 177d" style="background-color:#fffaf0;"></div>
[[Category: Patel, D.J.]]
== References ==
[[Category: Radhakrishnan, I.]]
<references/>
[[Category: dna]]
__TOC__
[[Category: nmr]]
</StructureSection>
[[Category: triplex]]
[[Category: Large Structures]]
 
[[Category: Patel DJ]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:06:09 2007''
[[Category: Radhakrishnan I]]

Latest revision as of 11:31, 22 November 2023

SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=177d&oldid=3962191"