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[[Image:1jlx.gif|left|200px]]<br />
<applet load="1jlx" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1jlx, resolution 2.2&Aring;" />
'''AGGLUTININ IN COMPLEX WITH T-DISACCHARIDE'''<br />


==Overview==
==AGGLUTININ IN COMPLEX WITH T-DISACCHARIDE==
Amaranthus caudatus agglutinin contains a novel arrangement of four, beta-trefoil domains. The sugar-binding site provides specificity for the, carcinoma-associated T-antigen disaccharide even when 'masked' by other, sugars.
<StructureSection load='1jlx' size='340' side='right'caption='[[1jlx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jlx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Amaranthus_caudatus Amaranthus caudatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MBN:TOLUENE'>MBN</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlx OCA], [https://pdbe.org/1jlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlx RCSB], [https://www.ebi.ac.uk/pdbsum/1jlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q71QF2_AMACA Q71QF2_AMACA]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Amaranthus caudatus agglutinin contains a novel arrangement of four beta-trefoil domains. The sugar-binding site provides specificity for the carcinoma-associated T-antigen disaccharide even when 'masked' by other sugars.


==About this Structure==
Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin.,Transue TR, Smith AK, Mo H, Goldstein IJ, Saper MA Nat Struct Biol. 1997 Oct;4(10):779-83. PMID:9334739<ref>PMID:9334739</ref>
1JLX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Amaranthus_caudatus Amaranthus caudatus]] with FOR and MBN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JLX OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin., Transue TR, Smith AK, Mo H, Goldstein IJ, Saper MA, Nat Struct Biol. 1997 Oct;4(10):779-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9334739 9334739]
</div>
<div class="pdbe-citations 1jlx" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Agglutinin 3D structures|Agglutinin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Amaranthus caudatus]]
[[Category: Amaranthus caudatus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Goldstein, I.J.]]
[[Category: Goldstein IJ]]
[[Category: Mo, H.]]
[[Category: Mo H]]
[[Category: Saper, M.A.]]
[[Category: Saper MA]]
[[Category: Smith, A.K.]]
[[Category: Smith AK]]
[[Category: Transue, T.R.]]
[[Category: Transue TR]]
[[Category: FOR]]
[[Category: MBN]]
[[Category: bivalent]]
[[Category: complex (lectin/saccharide)]]
[[Category: lectin]]
[[Category: t-disaccharide homodimer]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:23:12 2007''

Latest revision as of 06:27, 9 August 2023

AGGLUTININ IN COMPLEX WITH T-DISACCHARIDE

1jlx, resolution 2.20Å

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