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New page: left|200px<br /><applet load="1ims" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ims, resolution 1.500Å" /> '''MOLECULAR STRUCTURE...
 
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[[Image:1ims.gif|left|200px]]<br /><applet load="1ims" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ims, resolution 1.500&Aring;" />
'''MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)'''<br />


==Overview==
==MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)==
4'-Deoxy-4'-iododoxorubicin, a halogenated anthracycline derivative, is an, anticancer agent currently under Phase II clinical trials. In preclinical, studies, it has demonstrated significantly reduced levels of, cardiotoxicity compared to currently employed anthracyclines. It also has, modified pharmacological properties resulting in an altered spectrum of, experimental antitumor activity. The iodine atom at the 4' position of the, sugar ring reduces the basicity and enhances the lipophilicity of this, compound as compared to related anthracycline drugs. We report here single, crystal X-ray diffraction studies of the complexes of, 4'-deoxy-4'-iododoxorubicin with the hexanucleotide duplex sequences, d(TGTACA) and d(CGATCG) at 1.6 and 1.5 A, respectively. The iodine, substituent does not alter the geometry of intercalation as compared to, previously solved anthracycline complexes, but appears to markedly affect, the solvent environment of the structures. This could have consequences, for the interaction of this drug with DNA and DNA binding proteins in, cells.
<StructureSection load='1ims' size='340' side='right'caption='[[1ims]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ims]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IMS FirstGlance]. <br>
1IMS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DM7 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IMS OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DM7:4-DEOXY-4-IODODOXORUBICIN'>DM7</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ims FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ims OCA], [https://pdbe.org/1ims PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ims RCSB], [https://www.ebi.ac.uk/pdbsum/1ims PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ims ProSAT]</span></td></tr>
Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG)., Berger I, Su L, Spitzner JR, Kang C, Burke TG, Rich A, Nucleic Acids Res. 1995 Nov 11;23(21):4488-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7501474 7501474]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Berger, I.]]
</StructureSection>
[[Category: Burke, T.G.]]
[[Category: Large Structures]]
[[Category: Kang, C.]]
[[Category: Berger I]]
[[Category: Rich, A.]]
[[Category: Burke TG]]
[[Category: Spitzner, J.R.]]
[[Category: Kang C]]
[[Category: Su, L.]]
[[Category: Rich A]]
[[Category: DM7]]
[[Category: Spitzner JR]]
[[Category: complexed with drug]]
[[Category: Su L]]
[[Category: double helix]]
[[Category: right handed dna]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:14:09 2007''

Latest revision as of 07:36, 7 February 2024

MOLECULAR STRUCTURE OF THE HALOGENATED ANTI-CANCER DRUG IODODOXORUBICIN COMPLEXED WITH D(TGTACA) AND D(CGATCG)

1ims, resolution 1.50Å

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