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New page: left|200px<br /><applet load="1ehv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ehv, resolution 1.8Å" /> '''A NEW CRYSTAL STRUCTU...
 
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[[Image:1ehv.gif|left|200px]]<br /><applet load="1ehv" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ehv, resolution 1.8&Aring;" />
'''A NEW CRYSTAL STRUCTURE FOR THE DODECAMER C-G-C-G-A-A-T-T-C-G-C-G: SYMMETRY EFFECTS ON SEQUENCE-DEPENDENT DNA STRUCTURE'''<br />


==Overview==
==A NEW CRYSTAL STRUCTURE FOR THE DODECAMER C-G-C-G-A-A-T-T-C-G-C-G: SYMMETRY EFFECTS ON SEQUENCE-DEPENDENT DNA STRUCTURE==
The dodecanucleotide d(CGCGAATTCGCG) has been crystallised in the space, group P3(2)12, representing a new crystal form for this sequence. The, structure has been solved by molecular replacement and refined at 1.8 A, resolution. The present structure contrasts with previous ones for this, sequence since it is situated on a crystallographic 2-fold axis, and the, crystal symmetry reflects the palindromic nature of this sequence. Some, features accord with previous observations, notably that the minor groove, is hydrated with a continuous spine of solvent. There is no evidence of, alkali metal ions within this spine. The minor groove retains its narrow, width, although it is now symmetric and extends over the A/T tract., Various base and base-pair morphological parameters have been examined., Their values do not show significant correlations with earlier reports, suggesting that crystal packing effects on them are more dominant than has, been hitherto realised.
<StructureSection load='1ehv' size='340' side='right'caption='[[1ehv]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ehv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHV FirstGlance]. <br>
1EHV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EHV OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehv OCA], [https://pdbe.org/1ehv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehv RCSB], [https://www.ebi.ac.uk/pdbsum/1ehv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehv ProSAT]</span></td></tr>
==Reference==
</table>
A new crystal form for the dodecamer C-G-C-G-A-A-T-T-C-G-C-G: symmetry effects on sequence-dependent DNA structure., Johansson E, Parkinson G, Neidle S, J Mol Biol. 2000 Jul 14;300(3):551-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10884351 10884351]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Johansson, E.M.]]
[[Category: Large Structures]]
[[Category: crystal packing]]
[[Category: Johansson EM]]
[[Category: dickerson dodecamer]]
[[Category: dna]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:17:44 2007''

Latest revision as of 07:03, 7 February 2024

A NEW CRYSTAL STRUCTURE FOR THE DODECAMER C-G-C-G-A-A-T-T-C-G-C-G: SYMMETRY EFFECTS ON SEQUENCE-DEPENDENT DNA STRUCTURE

1ehv, resolution 1.80Å

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