3gv8: Difference between revisions

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{{Seed}}
[[Image:3gv8.jpg|left|200px]]


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==Human DNA polymerase iota in complex with T template DNA and incoming dGTP==
The line below this paragraph, containing "STRUCTURE_3gv8", creates the "Structure Box" on the page.
<StructureSection load='3gv8' size='340' side='right'caption='[[3gv8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gv8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GV8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3gv8| PDB=3gv8 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gv8 OCA], [https://pdbe.org/3gv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3gv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gv8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gv8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gv8 ConSurf].
<div style="clear:both"></div>


===Human DNA polymerase iota in complex with T template DNA and incoming dGTP===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 19440206 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_19440206}}
 
==About this Structure==
3GV8 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GV8 OCA].
 
==Reference==
<ref group="xtra">PMID:19440206</ref><references group="xtra"/>
[[Category: DNA-directed DNA polymerase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kirouac, K N.]]
[[Category: Large Structures]]
[[Category: Ling, H.]]
[[Category: Kirouac KN]]
[[Category: Dna damage]]
[[Category: Ling H]]
[[Category: Dna repair]]
[[Category: Dna replication]]
[[Category: Dna synthesis]]
[[Category: Dna-binding]]
[[Category: Dna-directed dna polymerase]]
[[Category: Error prone replication]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Mutator protein]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleus]]
[[Category: Polymerase iota]]
[[Category: Polymorphism]]
[[Category: Schiff base]]
[[Category: Transferase]]
[[Category: Transferase/dna complex]]
[[Category: Y-family polymerase]]
 
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Retrieved from "https://proteopedia.org/3gv8"