2zw9: Difference between revisions

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{{Seed}}
[[Image:2zw9.jpg|left|200px]]


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==Crystal structure of tRNA wybutosine synthesizing enzyme TYW4==
The line below this paragraph, containing "STRUCTURE_2zw9", creates the "Structure Box" on the page.
<StructureSection load='2zw9' size='340' side='right'caption='[[2zw9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZW9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
{{STRUCTURE_2zw9|  PDB=2zw9  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zw9 OCA], [https://pdbe.org/2zw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zw9 RCSB], [https://www.ebi.ac.uk/pdbsum/2zw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zw9 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of tRNA wybutosine synthesizing enzyme TYW4===
== Function ==
 
[https://www.uniprot.org/uniprot/TYW4_YEAST TYW4_YEAST] S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the final 2 independent reactions, methylation of the alpha-carboxy group of wybutosine-72 to form wybutosine-58, and methoxycarbonylation of alpha-amino group of wybutosine-58 through the fixation of CO(2) to complete wybutosine.<ref>PMID:16642040</ref> <ref>PMID:17150819</ref> <ref>PMID:19287006</ref>  
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/2zw9_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_19287006}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2ZW9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZW9 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zw9 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:19287006</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Ishitani, R.]]
[[Category: Ishitani R]]
[[Category: Noma, A.]]
[[Category: Noma A]]
[[Category: Nureki, O.]]
[[Category: Nureki O]]
[[Category: Suzuki, T.]]
[[Category: Suzuki T]]
[[Category: Suzuki, Y.]]
[[Category: Suzuki Y]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun  4 07:26:07 2009''

Latest revision as of 13:58, 13 March 2024

Crystal structure of tRNA wybutosine synthesizing enzyme TYW4

2zw9, resolution 2.50Å

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