3eil: Difference between revisions

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{{Seed}}
[[Image:3eil.jpg|left|200px]]


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==Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese==
The line below this paragraph, containing "STRUCTURE_3eil", creates the "Structure Box" on the page.
<StructureSection load='3eil' size='340' side='right'caption='[[3eil]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3eil]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EIL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
{{STRUCTURE_3eil|  PDB=3eil  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eil OCA], [https://pdbe.org/3eil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eil RCSB], [https://www.ebi.ac.uk/pdbsum/3eil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eil ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We present the structure of the duplex formed by a fragment of auto-complementary DNA with the sequence d(CGTTAATTAACG). The structure was determined by X-ray crystallography. Up to date it is the first structure presenting the interaction between a DNA oligonucleotide and manganese ions. The presence of Mn2+ creates bonds among the N7 atom of guanines and phosphates. These bonds stabilize and determine the crystallographic network in a P3(2) space group, unusual in oligonucleotide crystals. The crystal structure observed is compared with those found in the presence of Mg2+, Ca2+ and Ni2+, which show different kinds of interactions. The double helices show end-to-end interactions, in a manner that the terminal guanines interact with the minor groove of the neighboring duplex, while the terminal cytosines are disordered. We have chosen this sequence since it contains a TTAA repeat. Such repeats are very rare in all genomes. We suggest that this sequence may be very susceptible to the formation of closely spaced thymine dimers.


===Structure of B-DNA d(CGTTAATTAACG)2 in the presence of Manganese===
The interaction of manganese ions with DNA.,Millonig H, Pous J, Gouyette C, Subirana JA, Campos JL J Inorg Biochem. 2009 Jun;103(6):876-80. Epub 2009 Mar 25. PMID:19375803<ref>PMID:19375803</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3eil" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19375803 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19375803}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3EIL is a 6 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIL OCA].
[[Category: Campos LJ]]
 
[[Category: Millonig H]]
==Reference==
[[Category: Pous J]]
<ref group="xtra">PMID:19375803</ref><references group="xtra"/>
[[Category: Subirana JA]]
[[Category: Campos, L J.]]
[[Category: Millonig, H.]]
[[Category: Pous, J.]]
[[Category: Subirana, J A.]]
[[Category: B-dna]]
[[Category: Manganese]]
 
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Retrieved from "https://proteopedia.org/3eil"