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New page: left|200px<br /><applet load="1n1o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n1o, resolution 1.20Å" /> '''Crystal Structure of...
 
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[[Image:1n1o.gif|left|200px]]<br /><applet load="1n1o" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1n1o, resolution 1.20&Aring;" />
'''Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-threofuranosyl (3'-2') Nucleosides: A Four-Carbon Sugar is Easily Accommodated into the Backbone of DNA'''<br />


==Overview==
==Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-threofuranosyl (3'-2') Nucleosides: A Four-Carbon Sugar is Easily Accommodated into the Backbone of DNA==
(L)-alpha-Threofuranosyl-(3'--&gt;2')-oligonucleotides (TNA) containing, vicinally connected phosphodiester linkages undergo informational base, pairing in an antiparallel strand orientation and are capable of, cross-pairing with RNA and DNA. TNA is derived from a sugar containing, only four carbon atoms and is one of the simplest potentially natural, nucleic acid alternatives investigated thus far in the context of a, chemical etiology of nucleic acid structure. Compared to DNA and RNA that, contain six covalent bonds per repeating nucleotide unit, TNA contains, only five. We have determined the atomic-resolution crystal structure of, the B-form DNA duplex [d(CGCGAA)Td(TCGCG)](2) containing a single, (L)-alpha-threofuranosyl thymine (T) per strand. In the modified duplex, base stacking interactions are practically unchanged relative to the, reference DNA structure. The orientations of the backbone at the TNA, incorporation sites are slightly altered in order to accommodate fewer, atoms and covalent bonds. The conformation of the threose is C4'-exo with, the 2'- and 3'-substituents assuming quasi-diaxial orientation.
<StructureSection load='1n1o' size='340' side='right'caption='[[1n1o]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1n1o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1O FirstGlance]. <br>
1N1O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N1O OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TFT:(L)-ALPHA-THREOFURANOSYL-THYMINE-3-MONOPHOSPHATE'>TFT</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1o OCA], [https://pdbe.org/1n1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1o RCSB], [https://www.ebi.ac.uk/pdbsum/1n1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1o ProSAT]</span></td></tr>
Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'--&gt;2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA., Wilds CJ, Wawrzak Z, Krishnamurthy R, Eschenmoser A, Egli M, J Am Chem Soc. 2002 Nov 20;124(46):13716-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12431101 12431101]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Egli, M.]]
</StructureSection>
[[Category: Eschenmoser, A.]]
[[Category: Large Structures]]
[[Category: Krishnamurthy, R.]]
[[Category: Egli M]]
[[Category: Wawrzak, Z.]]
[[Category: Eschenmoser A]]
[[Category: Wilds, C.J.]]
[[Category: Krishnamurthy R]]
[[Category: MG]]
[[Category: Wawrzak Z]]
[[Category: b-dna]]
[[Category: Wilds CJ]]
[[Category: four-carbon sugar]]
[[Category: hydrogen bonding]]
[[Category: nucleic acid analogue]]
[[Category: nucleic acid etiology]]
[[Category: tetrose]]
[[Category: x-ray crystallography]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:24:21 2007''

Latest revision as of 07:51, 14 February 2024

Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-threofuranosyl (3'-2') Nucleosides: A Four-Carbon Sugar is Easily Accommodated into the Backbone of DNA

1n1o, resolution 1.20Å

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