1n96: Difference between revisions
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New page: left|200px<br /><applet load="1n96" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n96" /> '''DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCT... |
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== | ==DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)== | ||
The solution structure of a cyclic oligonucleotide d<pCGCTCATT> has been | <StructureSection load='1n96' size='340' side='right'caption='[[1n96]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1n96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N96 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n96 OCA], [https://pdbe.org/1n96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n96 RCSB], [https://www.ebi.ac.uk/pdbsum/1n96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n96 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The solution structure of a cyclic oligonucleotide d<pCGCTCATT> has been determined by two-dimensional NMR spectroscopy and restrained molecular dynamics. Under the appropriate experimental conditions, this molecule self-associates, forming a symmetric dimer stabilized by four intermolecular Watson-Crick base pairs. The resulting four-stranded structure consists of two G:C:A:T tetrads, formed by facing the minor groove side of the Watson-Crick base-pairs. Most probably, the association of the base-pairs is stabilized by coordinating a Na(+) cation. This is the first time that this novel G:C:A:T tetrad has been found in an oligonucleotide structure. This observation increases considerably the number of sequences that may adopt a four-stranded architecture. Overall, the three-dimensional structure is similar to those observed previously in other quadruplexes formed by minor groove alignment of Watson-Crick base pairs. This resemblance strongly suggests that we may be observing a general motif for DNA-DNA recognition. | |||
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad.,Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:12733903<ref>PMID:12733903</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: | <div class="pdbe-citations 1n96" style="background-color:#fffaf0;"></div> | ||
[[Category: Escaja | == References == | ||
[[Category: Gelpi | <references/> | ||
[[Category: Gonzalez | __TOC__ | ||
[[Category: Orozco | </StructureSection> | ||
[[Category: Pedroso | [[Category: Large Structures]] | ||
[[Category: Rico | [[Category: Escaja N]] | ||
[[Category: Gelpi JL]] | |||
[[Category: Gonzalez C]] | |||
[[Category: Orozco M]] | |||
[[Category: Pedroso E]] | |||
[[Category: Rico M]] | |||
Latest revision as of 18:52, 29 November 2023
DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)
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