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{{Seed}}
[[Image:1kpl.png|left|200px]]


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==Crystal Structure of the ClC Chloride Channel from S. typhimurium==
The line below this paragraph, containing "STRUCTURE_1kpl", creates the "Structure Box" on the page.
<StructureSection load='1kpl' size='340' side='right'caption='[[1kpl]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1kpl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KPL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1kpl|  PDB=1kpl  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kpl OCA], [https://pdbe.org/1kpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kpl RCSB], [https://www.ebi.ac.uk/pdbsum/1kpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kpl ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of the ClC Chloride Channel from S. typhimurium===
== Function ==
 
[https://www.uniprot.org/uniprot/CLCA_SALTY CLCA_SALTY] Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.<ref>PMID:11796999</ref>
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_11796999}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 11796999 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/1kpl_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11796999}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1KPL is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPL OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kpl ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:11796999</ref><references group="xtra"/>
<references/>
[[Category: Salmonella typhimurium]]
__TOC__
[[Category: Cadene, M.]]
</StructureSection>
[[Category: Campbell, E B.]]
[[Category: Large Structures]]
[[Category: Chait, B T.]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Dutzler, R.]]
[[Category: Cadene M]]
[[Category: MacKinnon, R.]]
[[Category: Campbell EB]]
[[Category: Helical membrane protein]]
[[Category: Chait BT]]
[[Category: Homodimer]]
[[Category: Dutzler R]]
[[Category: Ion channel]]
[[Category: MacKinnon R]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 23:10:00 2009''

Latest revision as of 07:26, 14 February 2024

Crystal Structure of the ClC Chloride Channel from S. typhimurium

1kpl, resolution 3.00Å

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