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New page: left|200px<br /><applet load="1evd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1evd" /> '''CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHI...
 
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[[Image:1evd.jpg|left|200px]]<br /><applet load="1evd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1evd" />
'''CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHIBITOR, NMR'''<br />


==Overview==
==NMR structure of CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHIBITOR==
A comparison of the structures of two cyanobacterial toxins yields, insights into how they may inhibit protein phosphatase-1 and -2A and why, microcystins but not motuporin may covalently modify their protein, phosphatase targets.
<StructureSection load='1evd' size='340' side='right'caption='[[1evd]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1evd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EVD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ZN:(2S,3S,4E,6E,8S,9S)-3-AMINO-9-METHOXY-2,6,8-TRIMETHYL-10-PHENYLDECA-4,6-DIENOIC+ACID'>1ZN</scene>, <scene name='pdbligand=ACB:3-METHYL-BETA-D-ASPARTIC+ACID'>ACB</scene>, <scene name='pdbligand=FGA:GAMMA-D-GLUTAMIC+ACID'>FGA</scene>, <scene name='pdbligand=MDH:N-METHYLDEHYDROBUTYRINE'>MDH</scene>, <scene name='pdbligand=PRD_000213:motuporin'>PRD_000213</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1evd OCA], [https://pdbe.org/1evd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1evd RCSB], [https://www.ebi.ac.uk/pdbsum/1evd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1evd ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A comparison of the structures of two cyanobacterial toxins yields insights into how they may inhibit protein phosphatase-1 and -2A and why microcystins but not motuporin may covalently modify their protein phosphatase targets.


==About this Structure==
Comparison of the solution structures of microcystin-LR and motuporin.,Bagu JR, Sonnichsen FD, Williams D, Andersen RJ, Sykes BD, Holmes CF Nat Struct Biol. 1995 Feb;2(2):114-6. PMID:7749913<ref>PMID:7749913</ref>
1EVD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Producing_organism_not_known Producing organism not known]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EVD OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Comparison of the solution structures of microcystin-LR and motuporin., Bagu JR, Sonnichsen FD, Williams D, Andersen RJ, Sykes BD, Holmes CF, Nat Struct Biol. 1995 Feb;2(2):114-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7749913 7749913]
</div>
[[Category: Producing organism not known]]
<div class="pdbe-citations 1evd" style="background-color:#fffaf0;"></div>
[[Category: Protein complex]]
== References ==
[[Category: Bagu, J.R.]]
<references/>
[[Category: Sykes, B.D.]]
__TOC__
[[Category: cyanobacterial toxin]]
</StructureSection>
[[Category: phosphatase-1/-2a inhibitor]]
[[Category: Large Structures]]
 
[[Category: Unidentified]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:52:31 2007''
[[Category: Bagu JR]]
[[Category: Sykes BD]]

Latest revision as of 07:49, 15 November 2023

NMR structure of CYANOBACTERIAL TOXIN, PHOSPHATASE-1/-2A INHIBITOR

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