3g9b: Difference between revisions
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< | ==Crystal structure of reduced Ost6L== | ||
<StructureSection load='3g9b' size='340' side='right'caption='[[3g9b]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3g9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G9B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g9b OCA], [https://pdbe.org/3g9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g9b RCSB], [https://www.ebi.ac.uk/pdbsum/3g9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g9b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OST6_YEAST OST6_YEAST] Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Can participate in redox reactions and is able to catalyze dithiol-disulfide exchange reactions with other proteins, albeit with relatively low efficiency. May form transient disulfide bonds with nascent polypeptides in the endoplasmic reticulum and thereby promote efficient glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal oligosaccharyl transferase activity.<ref>PMID:19549845</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/3g9b_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g9b ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Aebi | [[Category: Aebi M]] | ||
[[Category: Brozzo | [[Category: Brozzo MS]] | ||
[[Category: Capitani | [[Category: Capitani G]] | ||
[[Category: Fritsch | [[Category: Fritsch F]] | ||
[[Category: Glockshuber | [[Category: Glockshuber R]] | ||
[[Category: Grimshaw | [[Category: Grimshaw JPA]] | ||
[[Category: Gruetter | [[Category: Gruetter MG]] | ||
[[Category: Schulz | [[Category: Schulz BL]] | ||
[[Category: Stirnimann | [[Category: Stirnimann CU]] | ||
Latest revision as of 09:53, 21 February 2024
Crystal structure of reduced Ost6L
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