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New page: left|200px<br /><applet load="1vpd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vpd, resolution 1.65Å" /> '''X-Ray Crystal Struct...
 
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[[Image:1vpd.jpg|left|200px]]<br /><applet load="1vpd" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1vpd, resolution 1.65&Aring;" />
'''X-Ray Crystal Structure of Tartronate Semialdehyde Reductase [Salmonella Typhimurium LT2]'''<br />


==About this Structure==
==X-Ray Crystal Structure of Tartronate Semialdehyde Reductase [Salmonella Typhimurium LT2]==
1VPD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with CL and TLA as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 1TEA. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VPD OCA].  
<StructureSection load='1vpd' size='340' side='right'caption='[[1vpd]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
[[Category: Salmonella typhimurium]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[1vpd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tea 1tea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VPD FirstGlance]. <br>
[[Category: Collart, F.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
[[Category: Joachimiak, A.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vpd OCA], [https://pdbe.org/1vpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vpd RCSB], [https://www.ebi.ac.uk/pdbsum/1vpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vpd ProSAT], [https://www.topsan.org/Proteins/MCSG/1vpd TOPSAN]</span></td></tr>
[[Category: Moy, S.]]
</table>
[[Category: Osipiuk, J.]]
== Function ==
[[Category: Zhou, M.]]
[https://www.uniprot.org/uniprot/Q8ZLV8_SALTY Q8ZLV8_SALTY]  
[[Category: CL]]
== Evolutionary Conservation ==
[[Category: TLA]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: mcsg]]
Check<jmol>
[[Category: midwest center for structural genomics]]
  <jmolCheckbox>
[[Category: protein structure initiative]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/1vpd_consurf.spt"</scriptWhenChecked>
[[Category: psi]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: reductase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: structural genomics]]
  </jmolCheckbox>
[[Category: tartronate]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vpd ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tartronate semialdehyde reductases (TSRs), also known as 2-hydroxy-3-oxopropionate reductases, catalyze the reduction of tartronate semialdehyde using NAD as cofactor in the final stage of D: -glycerate biosynthesis. These enzymes belong to family of structurally and mechanically related beta-hydroxyacid dehydrogenases which differ in substrate specificity and catalyze reactions in specific metabolic pathways. Here, we present the crystal structure of GarR a TSR from Salmonella typhimurium determined by the single-wavelength anomalous diffraction method and refined to 1.65 A resolution. The active site of the enzyme contains L: -tartrate which most likely mimics a position of a glycerate which is a product of the enzyme reaction. The analysis of the TSR structure shows also a putative NADPH binding site in the enzyme.


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:56:41 2007''
X-Ray crystal structure of GarR-tartronate semialdehyde reductase from Salmonella typhimurium.,Osipiuk J, Zhou M, Moy S, Collart F, Joachimiak A J Struct Funct Genomics. 2009 Jan 28. PMID:19184529<ref>PMID:19184529</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1vpd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Collart F]]
[[Category: Joachimiak A]]
[[Category: Moy S]]
[[Category: Osipiuk J]]
[[Category: Zhou M]]
Retrieved from "https://proteopedia.org/1vpd"