3ggr: Difference between revisions

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{{Seed}}
[[Image:3ggr.jpg|left|200px]]


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==Crystal Structure of the Human Rad9-Hus1-Rad1 complex==
The line below this paragraph, containing "STRUCTURE_3ggr", creates the "Structure Box" on the page.
<StructureSection load='3ggr' size='340' side='right'caption='[[3ggr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ggr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggr OCA], [https://pdbe.org/3ggr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggr RCSB], [https://www.ebi.ac.uk/pdbsum/3ggr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggr ProSAT]</span></td></tr>
{{STRUCTURE_3ggr|  PDB=3ggr  |  SCENE=  }}
</table>
 
== Function ==
===Crystal Structure of the Human Rad9-Hus1-Rad1 complex===
[https://www.uniprot.org/uniprot/RAD9A_HUMAN RAD9A_HUMAN] Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.<ref>PMID:10713044</ref> <ref>PMID:21659603</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
3GGR is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGR OCA].  
  <jmolCheckbox>
[[Category: Exodeoxyribonuclease III]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3ggr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggr ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bai, L.]]
[[Category: Large Structures]]
[[Category: Hang, H Y.]]
[[Category: Bai L]]
[[Category: Jiang, T.]]
[[Category: Hang HY]]
[[Category: Xu, M.]]
[[Category: Jiang T]]
[[Category: Alternative splicing]]
[[Category: Xu M]]
[[Category: Cell cycle]]
[[Category: Cytoplasm]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Exonuclease]]
[[Category: Hydrolase]]
[[Category: Nuclease]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein-protein complex]]
 
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Retrieved from "https://proteopedia.org/3ggr"