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New page: left|200px<br /><applet load="1ndn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ndn, resolution 3.000Å" /> '''MOLECULAR STRUCTURE...
 
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[[Image:1ndn.jpg|left|200px]]<br /><applet load="1ndn" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ndn, resolution 3.000&Aring;" />
'''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''<br />


==Overview==
==MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4==
The molecular structure of a nicked dodecamer DNA double helix, made of a, ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG), oligonucleotides, has been determined by x-ray diffraction analysis at 3 A, resolution. The molecule adopts a B-DNA conformation, not unlike those, found in intact dodecamer DNA molecules crystallized in a somewhat, different crystal lattice, despite a gap due to the absence of a phosphate, group in the molecule. The helix has a distinct narrow minor groove near, the center of the molecule at the AAAA region. This suggests that the, internal stabilizing forces due to base stacking and hydrogen-bonding, interactions are sufficient to overcome the loss of connectivity, associated with the disruption of the covalent backbone of DNA.
<StructureSection load='1ndn' size='340' side='right'caption='[[1ndn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ndn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NDN FirstGlance]. <br>
1NDN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ndn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ndn OCA], [https://pdbe.org/1ndn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ndn RCSB], [https://www.ebi.ac.uk/pdbsum/1ndn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ndn ProSAT]</span></td></tr>
==Reference==
</table>
Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2320572 2320572]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Aymani, J.]]
[[Category: Large Structures]]
[[Category: Boom, J.H.Van.]]
[[Category: Aymani J]]
[[Category: Coll, M.]]
[[Category: Coll M]]
[[Category: Marel, G.A.Van.Der.]]
[[Category: Rich A]]
[[Category: Rich, A.]]
[[Category: Van Boom JH]]
[[Category: Wang, A.H.J.]]
[[Category: Van Der Marel GA]]
[[Category: b-dna]]
[[Category: Wang AH-J]]
[[Category: double helix]]
[[Category: nicked]]
 
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