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New page: left|200px<br /><applet load="1ngt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ngt, resolution 2.04Å" /> '''The Role of Minor Gr...
 
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[[Image:1ngt.gif|left|200px]]<br /><applet load="1ngt" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ngt, resolution 2.04&Aring;" />
'''The Role of Minor Groove Functional Groups in DNA Hydration'''<br />


==Overview==
==The Role of Minor Groove Functional Groups in DNA Hydration==
Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2, refined to 2.04 A. The modification, which affects only the two thymines, at the central ApT step, involves isosteric removal of the 2-keto oxygen, atoms and substitution of the N1 nitrogen with carbon. The crystal, structure reveals the ability of this modified thymine to effectively base, pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that, the minor groove 'spine of hydration' is destabilized but essentially, intact.
<StructureSection load='1ngt' size='340' side='right'caption='[[1ngt]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ngt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NGT FirstGlance]. <br>
1NGT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [https://pdbe.org/1ngt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB], [https://www.ebi.ac.uk/pdbsum/1ngt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ngt ProSAT]</span></td></tr>
The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12595562 12595562]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Lan, T.]]
</StructureSection>
[[Category: McLaughlin, L.W.]]
[[Category: Large Structures]]
[[Category: Williams, L.D.]]
[[Category: Lan T]]
[[Category: Woods, K.K.]]
[[Category: McLaughlin LW]]
[[Category: MG]]
[[Category: Williams LD]]
[[Category: dna conformation]]
[[Category: Woods KK]]
[[Category: modified base]]
[[Category: spine of hydration]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:06:58 2007''

Latest revision as of 07:56, 14 February 2024

The Role of Minor Groove Functional Groups in DNA Hydration

1ngt, resolution 2.04Å

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