2wci: Difference between revisions

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{{Seed}}
[[Image:2wci.jpg|left|200px]]


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==Structure of E. coli monothiol glutaredoxin GRX4 homodimer==
The line below this paragraph, containing "STRUCTURE_2wci", creates the "Structure Box" on the page.
<StructureSection load='2wci' size='340' side='right'caption='[[2wci]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2wci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
{{STRUCTURE_2wci|  PDB=2wci  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wci OCA], [https://pdbe.org/2wci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wci RCSB], [https://www.ebi.ac.uk/pdbsum/2wci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wci ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRX4_ECOLI GLRX4_ECOLI] Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wci_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wci ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Glutaredoxins (GRX) are redox proteins which use glutathione as a cofactor and are divided into two classes, monothiol and dithiol. In each class, several GRX have been shown to form [Fe2S2] cluster coordinating homodimers. The dithiol GRX homodimer is proposed to serve as a sequestration form and its iron-sulfur cluster as an oxidative stress sensor. In contrast, the monothiol GRX homodimer has been suggested to act as a scaffold for [Fe2S2] cluster delivery. We present here the structure of a monothiol GRX homodimer (Escherichia coli GRX4) coordinating a [Fe2S2] cluster that reveals the structural basis of intact iron-sulfur cluster delivery.


===STRUCTURE OF E. COLI MONOTHIOL GLUTAREDOXIN GRX4 HOMODIMER===
Structural Basis for Delivery of the Intact [Fe2S2] Cluster by Monothiol Glutaredoxin.,Iwema T, Picciocchi A, Traore DA, Ferrer JL, Chauvat F, Jacquamet L Biochemistry. 2009 Jun 15. PMID:19505088<ref>PMID:19505088</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_19505088}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2wci" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19505088 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19505088}}
__TOC__
 
</StructureSection>
==About this Structure==
2WCI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCI OCA].
 
==Reference==
<ref group="xtra">PMID:19505088</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Chauvat, F.]]
[[Category: Large Structures]]
[[Category: Ferrer, J L.]]
[[Category: Chauvat F]]
[[Category: Iwema, T.]]
[[Category: Ferrer J-L]]
[[Category: Jacquamet, L.]]
[[Category: Iwema T]]
[[Category: Picchiocci, A.]]
[[Category: Jacquamet L]]
[[Category: Traore, D A.K.]]
[[Category: Picchiocci A]]
[[Category: Cytoplasm]]
[[Category: Traore DAK]]
[[Category: Electron transport]]
[[Category: Fe2s2]]
[[Category: Glutathione]]
[[Category: Homodimer]]
[[Category: Iron-sulfur cluster scaffolder]]
[[Category: Redox-active center]]
[[Category: Thioredoxin fold]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 09:06:27 2009''

Latest revision as of 17:34, 8 September 2026

Structure of E. coli monothiol glutaredoxin GRX4 homodimer

2wci, resolution 1.90Å

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