2kfv: Difference between revisions
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< | ==Structure of the amino-terminal domain of human FK506-binding protein 3 / Northeast Structural Genomics Consortium Target HT99A== | ||
<StructureSection load='2kfv' size='340' side='right'caption='[[2kfv]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfv OCA], [https://pdbe.org/2kfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kfv RCSB], [https://www.ebi.ac.uk/pdbsum/2kfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kfv ProSAT], [https://www.topsan.org/Proteins/NESGC/2kfv TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FKBP3_HUMAN FKBP3_HUMAN] FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/2kfv_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kfv ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[FKBP 3D structures|FKBP 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Davis | [[Category: Davis T]] | ||
[[Category: Dhe-Paganon | [[Category: Dhe-Paganon S]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Fares | [[Category: Fares C]] | ||
[[Category: Gutmanas | [[Category: Gutmanas A]] | ||
[[Category: Lemak | [[Category: Lemak A]] | ||
[[Category: Li | [[Category: Li Y]] | ||
[[Category: Ouyang H]] | |||
[[Category: Ouyang | [[Category: Sunnerhagen M]] | ||
[[Category: Weigelt J]] | |||
[[Category: Sunnerhagen | |||
[[Category: Weigelt | |||
Latest revision as of 09:47, 9 May 2024
Structure of the amino-terminal domain of human FK506-binding protein 3 / Northeast Structural Genomics Consortium Target HT99A
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