3hym: Difference between revisions
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New page: '''Unreleased structure''' The entry 3hym is ON HOLD Authors: Wang, J., Dye, B.T., Rajashankar, K.R., Kurinov, I., Schulman, B.A. Description: Crystal Structure ''Page seeded by [http... |
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The | ==Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure== | ||
<StructureSection load='3hym' size='340' side='right'caption='[[3hym]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3hym]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HYM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hym OCA], [https://pdbe.org/3hym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hym RCSB], [https://www.ebi.ac.uk/pdbsum/3hym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hym ProSAT]</span></td></tr> | |||
</table> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hym_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hym ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein. | |||
Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.,Wang J, Dye BT, Rajashankar KR, Kurinov I, Schulman BA Nat Struct Mol Biol. 2009 Sep;16(9):987-9. Epub 2009 Aug 9. PMID:19668213<ref>PMID:19668213</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3hym" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dye BT]] | |||
[[Category: Kurinov I]] | |||
[[Category: Rajashankar KR]] | |||
[[Category: Schulman BA]] | |||
[[Category: Wang J]] | |||
