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New page: left|200px<br /><applet load="1w3z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w3z, resolution 3.2Å" /> '''SEMET DERIVATIVE OF B...
 
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[[Image:1w3z.gif|left|200px]]<br /><applet load="1w3z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1w3z, resolution 3.2&Aring;" />
'''SEMET DERIVATIVE OF BBCRASP-1 FROM BORRELIA BURGDORFERI'''<br />


==Overview==
==SeMet derivative of BbCRASP-1 from Borrelia Burgdorferi==
Borrelia burgdorferi, a spirochete transmitted to human hosts during, feeding of infected Ixodes ticks, is the causative agent of Lyme disease., Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form, of the disease and bind complement factor H (FH) and FH-like protein 1, (FHL-1) on the spirochete surface. Here we report the atomic structure for, the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer, that presents a novel target for drug design.
<StructureSection load='1w3z' size='340' side='right'caption='[[1w3z]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1w3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_ZS7 Borreliella burgdorferi ZS7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W3Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w3z OCA], [https://pdbe.org/1w3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w3z RCSB], [https://www.ebi.ac.uk/pdbsum/1w3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w3z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O50957_BORBU O50957_BORBU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w3z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w3z ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.


==About this Structure==
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.,Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564<ref>PMID:15711564</ref>
1W3Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W3Z OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15711564 15711564]
</div>
[[Category: Borrelia burgdorferi]]
<div class="pdbe-citations 1w3z" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
[[Category: Brade, V.]]
[[Category: Cordes, F.S.]]
[[Category: Goodstadt, L.]]
[[Category: Kirschfink, M.]]
[[Category: Kraiczy, P.]]
[[Category: Lea, S.M.]]
[[Category: Ponting, C.]]
[[Category: Roversi, P.]]
[[Category: Simon, M.M.]]
[[Category: Skerka, C.]]
[[Category: Wallich, R.]]
[[Category: Zipfel, P.]]
[[Category: complement regulator acquiring surface protein]]
[[Category: factor h binding]]
[[Category: lyme borreliosis]]
[[Category: selenomethionine]]
[[Category: tick]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:22:29 2007''
==See Also==
*[[Complement Regulator-Acquiring Surface Protein|Complement Regulator-Acquiring Surface Protein]]
*[[Complement regulator-acquiring surface protein|Complement regulator-acquiring surface protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Borreliella burgdorferi ZS7]]
[[Category: Large Structures]]
[[Category: Brade V]]
[[Category: Cordes FS]]
[[Category: Goodstadt L]]
[[Category: Kirschfink M]]
[[Category: Kraiczy P]]
[[Category: Lea SM]]
[[Category: Ponting C]]
[[Category: Roversi P]]
[[Category: Simon MM]]
[[Category: Skerka C]]
[[Category: Wallich R]]
[[Category: Zipfel P]]
Retrieved from "https://proteopedia.org/1w3z"