3hyz: Difference between revisions

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'''Unreleased structure'''


The entry 3hyz is ON HOLD
==Crystal structure of Hsp90 with fragment 42-C03==
<StructureSection load='3hyz' size='340' side='right'caption='[[3hyz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3hyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HYZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hyz OCA], [https://pdbe.org/3hyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hyz RCSB], [https://www.ebi.ac.uk/pdbsum/3hyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hyz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hyz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hyz ConSurf].
<div style="clear:both"></div>


Authors: Barker, J., Mather, O., Cheng, R.K.Y., Palan, S., Felicetti, B., Whittaker, M.
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
Description: Crystal structure of Hsp90 with fragment 42-C03
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  8 09:15:33 2009''
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barker J]]
[[Category: Cheng RKY]]
[[Category: Felicetti B]]
[[Category: Mather O]]
[[Category: Palan S]]
[[Category: Whittaker M]]
Retrieved from "https://proteopedia.org/3hyz"