2klc: Difference between revisions
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==NMR solution structure of human ubiquitin-like domain of ubiquilin 1, Northeast Structural Genomics Consortium (NESG) target HT5A== | |||
<StructureSection load='2klc' size='340' side='right'caption='[[2klc]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2klc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klc OCA], [https://pdbe.org/2klc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klc RCSB], [https://www.ebi.ac.uk/pdbsum/2klc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UBQL1_HUMAN UBQL1_HUMAN] Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
== | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klc_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2klc ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Dhe-Paganon | [[Category: Arrowsmith CH]] | ||
[[Category: Doherty | [[Category: Dhe-Paganon S]] | ||
[[Category: Fares | [[Category: Doherty RS]] | ||
[[Category: Garcia | [[Category: Fares C]] | ||
[[Category: Gutmanas | [[Category: Garcia M]] | ||
[[Category: Lemak | [[Category: Gutmanas A]] | ||
[[Category: Montelione | [[Category: Lemak S]] | ||
[[Category: Montelione GT]] | |||
[[Category: Yee A]] | |||
[[Category: Yee | |||
Latest revision as of 06:46, 1 May 2024
NMR solution structure of human ubiquitin-like domain of ubiquilin 1, Northeast Structural Genomics Consortium (NESG) target HT5A
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