3dr8: Difference between revisions

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{{Seed}}
[[Image:3dr8.png|left|200px]]


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==Structure of yncA, a putative ACETYLTRANSFERASE from Salmonella typhimurium with its cofactor Acetyl-CoA==
The line below this paragraph, containing "STRUCTURE_3dr8", creates the "Structure Box" on the page.
<StructureSection load='3dr8' size='340' side='right'caption='[[3dr8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DR8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3dr8|  PDB=3dr8  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dr8 OCA], [https://pdbe.org/3dr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dr8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dr8 ProSAT]</span></td></tr>
 
</table>
===Structure of yncA, a putative ACETYLTRANSFERASE from Salmonella typhimurium with its cofactor Acetyl-CoA===
== Function ==
 
[https://www.uniprot.org/uniprot/MDDA_SALTY MDDA_SALTY] Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), a rare amino acid which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of MSX. It can also use L-methionine sulfone (MSO) (PubMed:25368301). Also catalyzes the acylation of free L-amino acids using an acyl-CoA as acyl donor (By similarity).[UniProtKB:P76112]<ref>PMID:25368301</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3DR8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DR8 OCA].  
Check<jmol>
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
  <jmolCheckbox>
[[Category: Anderson, W F.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dr8_consurf.spt"</scriptWhenChecked>
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Edwards, A M.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Onopriyenko, O.]]
  </jmolCheckbox>
[[Category: Savchenko, A.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dr8 ConSurf].
[[Category: Singer, A U.]]
<div style="clear:both"></div>
[[Category: Skarina, T.]]
== References ==
[[Category: Center for structural genomics of infectious disease]]
<references/>
[[Category: Csgid]]
__TOC__
[[Category: Salmonella essential gene idp0086 acetyltranferase cofactor acetyl-coa]]
</StructureSection>
[[Category: Structural genomic]]
[[Category: Large Structures]]
[[Category: Transferase. funded by the national institute of allergy and infectious diseases of nih contract number hhsn272200700058c]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
 
[[Category: Anderson WF]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 15 14:00:16 2009''
[[Category: Edwards AM]]
[[Category: Onopriyenko O]]
[[Category: Savchenko A]]
[[Category: Singer AU]]
[[Category: Skarina T]]

Latest revision as of 09:00, 30 October 2024

Structure of yncA, a putative ACETYLTRANSFERASE from Salmonella typhimurium with its cofactor Acetyl-CoA

3dr8, resolution 1.95Å

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