1fmq: Difference between revisions

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New page: left|200px<br /><applet load="1fmq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fmq, resolution 2.Å" /> '''Cyclo-butyl-bis-furami...
 
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[[Image:1fmq.gif|left|200px]]<br /><applet load="1fmq" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1fmq, resolution 2.&Aring;" />
'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''<br />


==Overview==
==Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG==
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and, 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against, Pneumocystis carinii and also show cytotoxicity against several tumour, cell lines. These activities are correlated with DNA-binding abilities;, the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG), is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
<StructureSection load='1fmq' size='340' side='right'caption='[[1fmq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1fmq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMQ FirstGlance]. <br>
1FMQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and D34 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [https://pdbe.org/1fmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB], [https://www.ebi.ac.uk/pdbsum/1fmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fmq ProSAT]</span></td></tr>
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11128631 11128631]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Boykin, D.W.]]
</StructureSection>
[[Category: Kumar, A.]]
[[Category: Large Structures]]
[[Category: Lee, M.]]
[[Category: Boykin DW]]
[[Category: Neidle, S.]]
[[Category: Kumar A]]
[[Category: Simpson, I.J.]]
[[Category: Lee M]]
[[Category: D34]]
[[Category: Neidle S]]
[[Category: MG]]
[[Category: Simpson IJ]]
[[Category: dna-drug minor groove complex]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:04:15 2007''

Latest revision as of 07:16, 7 February 2024

Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG

1fmq, resolution 2.00Å

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