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New page: left|200px<br /><applet load="1o0k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o0k, resolution 1.17Å" /> '''Structure of the Fir...
 
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[[Image:1o0k.gif|left|200px]]<br /><applet load="1o0k" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1o0k, resolution 1.17&Aring;" />
'''Structure of the First Parallel DNA Quadruplex-drug Complex'''<br />


==Overview==
==Structure of the First Parallel DNA Quadruplex-drug Complex==
The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
<StructureSection load='1o0k' size='340' side='right'caption='[[1o0k]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1o0k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O0K FirstGlance]. <br>
1O0K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DM1 and NA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.17&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0k OCA], [https://pdbe.org/1o0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o0k RCSB], [https://www.ebi.ac.uk/pdbsum/1o0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o0k ProSAT]</span></td></tr>
Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12670225 12670225]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Clark, G.R.]]
</StructureSection>
[[Category: Neidle, S.]]
[[Category: Large Structures]]
[[Category: Pytel, P.D.]]
[[Category: Clark GR]]
[[Category: Squire, C.J.]]
[[Category: Neidle S]]
[[Category: DM1]]
[[Category: Pytel PD]]
[[Category: NA]]
[[Category: Squire CJ]]
[[Category: g-4 quadruplex drug complex]]
[[Category: parallel quadruplex]]
 
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