2kmi: Difference between revisions
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New page: '''Unreleased structure''' The entry 2kmi is ON HOLD Authors: Chen, J., Wang, J. Description: MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of L... |
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==MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6== | |||
<StructureSection load='2kmi' size='340' side='right'caption='[[2kmi]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmi OCA], [https://pdbe.org/2kmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmi RCSB], [https://www.ebi.ac.uk/pdbsum/2kmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmi ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kmi_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kmi ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Chen J]] | |||
[[Category: Wang J]] | |||
Latest revision as of 09:40, 22 May 2024
MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6
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