3ih7: Difference between revisions
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New page: '''Unreleased structure''' The entry 3ih7 is ON HOLD Authors: Verdine, G.L., Crenshaw, C.M., Oo, K.S., Kutchukian, P.S. Description: Crystal structure of catalytically active human 8-o... |
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==Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA== | |||
<StructureSection load='3ih7' size='340' side='right'caption='[[3ih7]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ih7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IH7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ih7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ih7 OCA], [https://pdbe.org/3ih7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ih7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ih7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ih7 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | |||
==See Also== | |||
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Crenshaw CM]] | |||
[[Category: Kutchukian PS]] | |||
[[Category: Oo KS]] | |||
[[Category: Verdine GL]] | |||
