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New page: left|200px<br /><applet load="1bn9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn9" /> '''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEP...
 
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[[Image:1bn9.gif|left|200px]]<br /><applet load="1bn9" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bn9" />
'''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA'''<br />


==Overview==
==RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA==
Rev-erb beta is an orphan receptor that binds as a homodimer or as a, monomer to DNA. The solution structure of the non-palindromic 15 bp DNA, duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for, monomeric binding, was determined by 1H and 31P NMR, energy minimization, with NMR-derived restraints for distances and NOE back-calculation, methods. The refined final structures have the typical overall features of, B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA, binding domain of Rev-erb beta, showed large shifts of imino protons and, 31P signals, suggesting major conformational changes.
<StructureSection load='1bn9' size='340' side='right'caption='[[1bn9]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bn9]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BN9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn9 OCA], [https://pdbe.org/1bn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bn9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bn9 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes.


==About this Structure==
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*.,Castagne C, Terenzi H, Zakin MM, Delepierre M Biochimie. 2000 Aug;82(8):739-48. PMID:11018291<ref>PMID:11018291</ref>
1BN9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN9 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11018291 11018291]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1bn9" style="background-color:#fffaf0;"></div>
[[Category: Castagne, C.]]
== References ==
[[Category: Delepierre, M.]]
<references/>
[[Category: Terenzi, H.]]
__TOC__
[[Category: Zakin, M.M.]]
</StructureSection>
[[Category: dna]]
[[Category: Large Structures]]
[[Category: orphan nuclear receptor]]
[[Category: Castagne C]]
[[Category: response element]]
[[Category: Delepierre M]]
 
[[Category: Terenzi H]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:23:14 2007''
[[Category: Zakin MM]]
Retrieved from "https://proteopedia.org/1bn9"