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New page: left|200px<br /><applet load="1woq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1woq, resolution 1.80Å" /> '''Crystal Structure of...
 
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[[Image:1woq.jpg|left|200px]]<br /><applet load="1woq" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1woq, resolution 1.80&Aring;" />
'''Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution'''<br />


==Overview==
==Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution==
Inorganic polyphosphate (poly(P)) is a biological high energy compound, presumed to be an ancient energy carrier preceding ATP. Several, poly(P)-dependent kinases that use poly(P) as a phosphoryl donor are known, to function in bacteria, but crystal structures of these kinases have not, been solved. Here we present the crystal structure of bacterial, poly(P)/ATP-glucomannokinase, belonging to Gram-positive bacterial, glucokinase, complexed with 1 glucose molecule and 2 phosphate molecules, at 1.8 A resolution, being the first among poly(P)-dependent kinases and, bacterial glucokinases. The poly(P)/ATP-glucomannokinase structure enabled, us to understand the structural relationship of bacterial glucokinase to, eucaryotic hexokinase and ADP-glucokinase, which has remained a matter of, debate. These comparisons also enabled us to propose putative binding, sites for phosphoryl groups for ATP and especially for poly(P) and to, obtain insights into the evolution of kinase, particularly from primordial, poly(P)-specific to ubiquitous ATP-specific proteins.
<StructureSection load='1woq' size='340' side='right'caption='[[1woq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1woq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_sp._KM Arthrobacter sp. KM]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WOQ FirstGlance]. <br>
1WOQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_sp. Arthrobacter sp.] with GLC and PO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Polyphosphate--glucose_phosphotransferase Polyphosphate--glucose phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.63 2.7.1.63] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WOQ OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1woq OCA], [https://pdbe.org/1woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1woq RCSB], [https://www.ebi.ac.uk/pdbsum/1woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1woq ProSAT]</span></td></tr>
Crystal structure of bacterial inorganic polyphosphate/ATP-glucomannokinase. Insights into kinase evolution., Mukai T, Kawai S, Mori S, Mikami B, Murata K, J Biol Chem. 2004 Nov 26;279(48):50591-600. Epub 2004 Sep 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15377666 15377666]
</table>
[[Category: Arthrobacter sp.]]
== Function ==
[[Category: Polyphosphate--glucose phosphotransferase]]
[https://www.uniprot.org/uniprot/Q7WT42_ARTSK Q7WT42_ARTSK]  
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Kawai, S.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Mikami, B.]]
Check<jmol>
[[Category: Mori, S.]]
  <jmolCheckbox>
[[Category: Mukai, T.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/1woq_consurf.spt"</scriptWhenChecked>
[[Category: Murata, K.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: GLC]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: PO4]]
  </jmolCheckbox>
[[Category: atp]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1woq ConSurf].
[[Category: glucomannokinase]]
<div style="clear:both"></div>
[[Category: polyphosphate]]
__TOC__
 
</StructureSection>
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:26:51 2007''
[[Category: Arthrobacter sp. KM]]
[[Category: Large Structures]]
[[Category: Kawai S]]
[[Category: Mikami B]]
[[Category: Mori S]]
[[Category: Mukai T]]
[[Category: Murata K]]

Latest revision as of 13:33, 13 March 2024

Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution

1woq, resolution 1.80Å

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