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New page: left|200px<br /><applet load="1br3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1br3, resolution 3.00Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1br3.gif|left|200px]]<br /><applet load="1br3" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1br3, resolution 3.00&Aring;" />
'''CRYSTAL STRUCTURE OF AN 82-NUCLEOTIDE RNA-DNA COMPLEX FORMED BY THE 10-23 DNA ENZYME'''<br />


==Overview==
==CRYSTAL STRUCTURE OF AN 82-NUCLEOTIDE RNA-DNA COMPLEX FORMED BY THE 10-23 DNA ENZYME==
The structure of a large nucleic acid complex formed by the 10-23 DNA, enzyme bound to an RNA substrate was determined by X-ray diffraction at, 3.0 A resolution. The 82-nucleotide complex contains two strands of DNA, and two strands of RNA that form five double-helical domains. The spatial, arrangement of these helices is maintained by two four-way junctions that, exhibit extensive base-stacking interactions and sharp turns of the, phosphodiester backbone stabilized by metal ions coordinated to, nucleotides at these junctions. Although it is unlikely that the structure, corresponds to the catalytically active conformation of the enzyme, it, represents a novel nucleic acid fold with implications for the Holliday, junction structure.
<StructureSection load='1br3' size='340' side='right'caption='[[1br3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1br3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BR3 FirstGlance]. <br>
1BR3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BR3 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1br3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br3 OCA], [https://pdbe.org/1br3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br3 RCSB], [https://www.ebi.ac.uk/pdbsum/1br3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br3 ProSAT]</span></td></tr>
==Reference==
</table>
Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme., Nowakowski J, Shim PJ, Prasad GS, Stout CD, Joyce GF, Nat Struct Biol. 1999 Feb;6(2):151-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10048927 10048927]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Joyce, G.F.]]
[[Category: Large Structures]]
[[Category: Nowakowski, J.]]
[[Category: Joyce GF]]
[[Category: Prasad, G.S.]]
[[Category: Nowakowski J]]
[[Category: Shim, P.J.]]
[[Category: Prasad GS]]
[[Category: Stout, C.D.]]
[[Category: Shim PJ]]
[[Category: dna enzyme]]
[[Category: Stout CD]]
[[Category: holliday junction]]
[[Category: ribozyme]]
 
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