2wq4: Difference between revisions
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New page: '''Unreleased structure''' The entry 2wq4 is ON HOLD Authors: Sulak, O., Cioci, G., Lahman, M., Delia, M., Varrot, A., Imberty, A., Wimmerova, M. Description: N-terminal domain of BC2L... |
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The | ==N-terminal domain of BC2L-C Lectin from Burkholderia cenocepacia== | ||
<StructureSection load='2wq4' size='340' side='right'caption='[[2wq4]], [[Resolution|resolution]] 1.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2wq4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia_J2315 Burkholderia cenocepacia J2315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQ4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SFU:METHYL+6-DEOXY-1-SELENO-ALPHA-L-GALACTOPYRANOSIDE'>SFU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wq4 OCA], [https://pdbe.org/2wq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wq4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B4EH86_BURCJ B4EH86_BURCJ] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The opportunistic pathogen Burkholderia cenocepacia expresses several soluble lectins, among them BC2L-C. This lectin exhibits two domains: a C-terminal domain with high sequence similarity to the recently described calcium-dependent mannose-binding lectin BC2L-A, and an N-terminal domain of 156 amino acids without similarity to any known protein. The recombinant N-terminal BC2L-C domain is a new lectin with specificity for fucosylated human histo-blood group epitopes H-type 1, Lewis b, and Lewis Y, as determined by glycan array and isothermal titration calorimetry. Methylselenofucoside was used as ligand to solve the crystal structure of the N-terminal BC2L-C domain. Additional molecular modeling studies rationalized the preference for Lewis epitopes. The structure reveals a trimeric jellyroll arrangement with striking similarity to TNF-like proteins, and to BclA, the spore protein from Bacillus anthracis which may play an important role in bioadhesion of anthrax spores in human lungs. | |||
A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens.,Sulak O, Cioci G, Delia M, Lahmann M, Varrot A, Imberty A, Wimmerova M Structure. 2010 Jan 13;18(1):59-72. PMID:20152153<ref>PMID:20152153</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2wq4" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Burkholderia cenocepacia J2315]] | |||
[[Category: Large Structures]] | |||
[[Category: Cioci G]] | |||
[[Category: Delia M]] | |||
[[Category: Imberty A]] | |||
[[Category: Lahman M]] | |||
[[Category: Sulak O]] | |||
[[Category: Varrot A]] | |||
[[Category: Wimmerova M]] | |||
Latest revision as of 05:34, 17 October 2024
N-terminal domain of BC2L-C Lectin from Burkholderia cenocepacia
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