3ime: Difference between revisions

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New page: '''Unreleased structure''' The entry 3ime is ON HOLD until Paper Publication Authors: Ciulli, A., Hung, A.W., Silvestre, H.L., Wen, S., Blundell, T.L., Abell, C. Description: Crystal S...
 
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'''Unreleased structure'''


The entry 3ime is ON HOLD  until Paper Publication
==Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.40 Ang resolution in complex with fragment compound 1-Benzofuran-2-carboxylic acid==
<StructureSection load='3ime' size='340' side='right'caption='[[3ime]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ime]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IME FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZ2:1-BENZOFURAN-2-CARBOXYLIC+ACID'>BZ2</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ime FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ime OCA], [https://pdbe.org/3ime PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ime RCSB], [https://www.ebi.ac.uk/pdbsum/3ime PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ime ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3ime_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ime ConSurf].
<div style="clear:both"></div>


Authors: Ciulli, A., Hung, A.W., Silvestre, H.L., Wen, S., Blundell, T.L., Abell, C.
==See Also==
 
*[[Pantothenate synthetase|Pantothenate synthetase]]
Description: Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.40 Ang resolution in complex with fragment compound 1-Benzofuran-2-carboxylic acid
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 12:37:33 2009''
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Abell C]]
[[Category: Blundell TL]]
[[Category: Ciulli A]]
[[Category: Hung AW]]
[[Category: Silvestre HL]]
[[Category: Wen S]]
Retrieved from "https://proteopedia.org/3ime"