3e4d: Difference between revisions

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{{Seed}}
[[Image:3e4d.jpg|left|200px]]


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==Structural and Kinetic Study of an S-Formylglutathione Hydrolase from Agrobacterium tumefaciens==
The line below this paragraph, containing "STRUCTURE_3e4d", creates the "Structure Box" on the page.
<StructureSection load='3e4d' size='340' side='right'caption='[[3e4d]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e4d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_fabrum_str._C58 Agrobacterium fabrum str. C58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3e4d|  PDB=3e4d  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4d OCA], [https://pdbe.org/3e4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4d RCSB], [https://www.ebi.ac.uk/pdbsum/3e4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A9CJ11_AGRFC A9CJ11_AGRFC] Serine hydrolase involved in the detoxification of formaldehyde.[RuleBase:RU363068]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/3e4d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e4d ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the Atu1476 protein from Agrobacterium tumefaciens was determined at 2 A resolution. The crystal structure and biochemical characterization of this enzyme support the conclusion that this protein is an S-formylglutathione hydrolase (AtuSFGH). The three dimensional structure of AtuSFGH contains the alpha/beta hydrolase fold topology and exists as a homo-dimer. Contacts between the two monomers in the dimer are formed both by hydrogen bonds and salt bridges. Biochemical characterization reveals that AtuSFGH hydrolyzes C-O bonds with high affinity towards short to medium chain esters, unlike the other known SFGHs which have greater affinity towards shorter chained esters. A potential role for Cys54 in regulation of enzyme activity through S-glutathionylation is also proposed.


===Structural and Kinetic Study of an S-Formylglutathione Hydrolase from Agrobacterium tumefaciens===
The structure of a putative S-formylglutathione hydrolase from agrobacterium tumefaciens.,van Straaten KE, Gonzalez CF, Valladares RB, Xu X, Savchenko AV, Sanders DA Protein Sci. 2009 Aug 3. PMID:19653299<ref>PMID:19653299</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19653299}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3e4d" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19653299 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19653299}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Agrobacterium fabrum str. C58]]
3E4D is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4D OCA].
[[Category: Large Structures]]
 
[[Category: Gonzalez CF]]
==Reference==
[[Category: Sanders DAR]]
<ref group="xtra">PMID:19653299</ref><references group="xtra"/>
[[Category: Savchenko AV]]
[[Category: Agrobacterium tumefaciens]]
[[Category: Valladares RB]]
[[Category: Gonzalez, C F.]]
[[Category: Van Straaten KE]]
[[Category: Sanders, D A.R.]]
[[Category: Xu X]]
[[Category: Savchenko, A V.]]
[[Category: Straaten, K E.Van.]]
[[Category: Valladares, R B.]]
[[Category: Xu, X.]]
[[Category: Catalytic triad]]
[[Category: Hydrolase fold family]]
[[Category: Kinetic]]
[[Category: Proposed reaction mechanism]]
[[Category: S-formylglutathione hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:08:42 2009''
Retrieved from "https://proteopedia.org/3e4d"