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New page: left|200px<br /><applet load="1smz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1smz" /> '''Structure of Transportan in phospholipid bic...
 
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[[Image:1smz.gif|left|200px]]<br /><applet load="1smz" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1smz" />
'''Structure of Transportan in phospholipid bicellar solution'''<br />


==Overview==
==Structure of Transportan in phospholipid bicellar solution==
Transportan is a chimeric cell-penetrating peptide constructed from the, peptides galanin and mastoparan, which has the ability to internalize, living cells carrying a hydrophilic load. In this study, we have, determined the NMR solution structure and investigated the position of, transportan in neutral bicelles. The structure revealed a well-defined, alpha-helix in the C-terminal mastoparan part of the peptide and a weaker, tendency to form an alpha-helix in the N-terminal domain. The position of, the peptide in relation to the membrane, as studied by adding paramagnetic, probes, shows that the peptide lies parallel to, and in the head-group, region of the membrane surface. This result is supported by amide proton, secondary chemical shifts.
<StructureSection load='1smz' size='340' side='right'caption='[[1smz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1smz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smz OCA], [https://pdbe.org/1smz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smz RCSB], [https://www.ebi.ac.uk/pdbsum/1smz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smz ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.


==About this Structure==
NMR solution structure and position of transportan in neutral phospholipid bicelles.,Barany-Wallje E, Andersson A, Graslund A, Maler L FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334<ref>PMID:15178334</ref>
1SMZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
NMR solution structure and position of transportan in neutral phospholipid bicelles., Barany-Wallje E, Andersson A, Graslund A, Maler L, FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15178334 15178334]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1smz" style="background-color:#fffaf0;"></div>
[[Category: Andersson, A.]]
== References ==
[[Category: Barany-Wallje, E.]]
<references/>
[[Category: Graslund, A.]]
__TOC__
[[Category: Maler, L.]]
</StructureSection>
[[Category: transport protein]]
[[Category: Large Structures]]
 
[[Category: Andersson A]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:48:16 2007''
[[Category: Barany-Wallje E]]
[[Category: Graslund A]]
[[Category: Maler L]]
Retrieved from "https://proteopedia.org/1smz"