3ipu: Difference between revisions
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New page: '''Unreleased structure''' The entry 3ipu is ON HOLD Authors: Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGu... |
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==X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha== | |||
<StructureSection load='3ipu' size='340' side='right'caption='[[3ipu]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ipu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O40:4-{[METHYL(3-{[7-PROPYL-3-(TRIFLUOROMETHYL)-1,2-BENZISOXAZOL-6-YL]OXY}PROPYL)CARBAMOYL]AMINO}BENZOIC+ACID'>O40</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipu OCA], [https://pdbe.org/3ipu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipu RCSB], [https://www.ebi.ac.uk/pdbsum/3ipu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NR1H3_HUMAN NR1H3_HUMAN] Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipu_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ipu ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Liver X receptor|Liver X receptor]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bennet DJ]] | |||
[[Category: Cooke AJ]] | |||
[[Category: Fradera X]] | |||
[[Category: Haunso A]] | |||
[[Category: Hosfield D]] | |||
[[Category: King A]] | |||
[[Category: McGuire R]] | |||
[[Category: Nimz O]] | |||
[[Category: Skene R]] | |||
[[Category: Uitdehaag JCM]] | |||
[[Category: Vu D]] | |||
[[Category: Wijnands R]] | |||
