2j3t: Difference between revisions

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{{Seed}}
[[Image:2j3t.png|left|200px]]


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==The crystal structure of the bet3-trs33-bet5-trs23 complex.==
The line below this paragraph, containing "STRUCTURE_2j3t", creates the "Structure Box" on the page.
<StructureSection load='2j3t' size='340' side='right'caption='[[2j3t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2j3t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J3T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
{{STRUCTURE_2j3t|  PDB=2j3t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j3t OCA], [https://pdbe.org/2j3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j3t RCSB], [https://www.ebi.ac.uk/pdbsum/2j3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j3t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPPC3_MOUSE TPPC3_MOUSE] May play a role in vesicular transport from endoplasmic reticulum to Golgi.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j3t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j3t ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Transport protein particle (TRAPP) I is a multisubunit vesicle tethering factor composed of seven subunits involved in ER-to-Golgi trafficking. The functional mechanism of the complex and how the subunits interact to form a functional unit are unknown. Here, we have used a multidisciplinary approach that includes X-ray crystallography, electron microscopy, biochemistry, and yeast genetics to elucidate the architecture of TRAPP I. The complex is organized through lateral juxtaposition of the subunits into a flat and elongated particle. We have also localized the site of guanine nucleotide exchange activity to a highly conserved surface encompassing several subunits. We propose that TRAPP I attaches to Golgi membranes with its large flat surface containing many highly conserved residues and forms a platform for protein-protein interactions. This study provides the most comprehensive view of a multisubunit vesicle tethering complex to date, based on which a model for the function of this complex, involving Rab1-GTP and long, coiled-coil tethers, is presented.


===THE CRYSTAL STRUCTURE OF THE BET3-TRS33-BET5-TRS23 COMPLEX.===
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering.,Kim YG, Raunser S, Munger C, Wagner J, Song YL, Cygler M, Walz T, Oh BH, Sacher M Cell. 2006 Nov 17;127(4):817-30. PMID:17110339<ref>PMID:17110339</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_17110339}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2j3t" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17110339 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17110339}}
__TOC__
 
</StructureSection>
==About this Structure==
2J3T is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3T OCA].
 
==Reference==
<ref group="xtra">PMID:17110339</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Kim, Y.]]
[[Category: Kim Y]]
[[Category: Oh, B.]]
[[Category: Oh B]]
[[Category: Alternative splicing]]
[[Category: Endoplasmic reticulum]]
[[Category: Er-golgi transport]]
[[Category: Golgi apparatus]]
[[Category: Lipoprotein]]
[[Category: Multisubunit tethering factor]]
[[Category: Palmitate]]
[[Category: Protein transport]]
[[Category: Transport]]
[[Category: Trapp]]
[[Category: Vesicle transport]]
 
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Retrieved from "https://proteopedia.org/2j3t"