3hcs: Difference between revisions

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{{Seed}}
[[Image:3hcs.png|left|200px]]


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==Crystal structure of the N-terminal domain of TRAF6==
The line below this paragraph, containing "STRUCTURE_3hcs", creates the "Structure Box" on the page.
<StructureSection load='3hcs' size='340' side='right'caption='[[3hcs]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hcs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HCS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3hcs| PDB=3hcs |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hcs OCA], [https://pdbe.org/3hcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hcs RCSB], [https://www.ebi.ac.uk/pdbsum/3hcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hcs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/3hcs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hcs ConSurf].
<div style="clear:both"></div>


===Crystal structure of the N-terminal domain of TRAF6===
==See Also==
 
*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_19465916}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 19465916 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_19465916}}
 
==About this Structure==
3HCS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCS OCA].
 
==Reference==
<ref group="xtra">PMID:19465916</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Campos, A D.]]
[[Category: Large Structures]]
[[Category: Darnay, B G.]]
[[Category: Campos AD]]
[[Category: Hura, G.]]
[[Category: Darnay BG]]
[[Category: Lamothe, B.]]
[[Category: Hura G]]
[[Category: Lenardo, M J.]]
[[Category: Lamothe B]]
[[Category: Lin, S C.]]
[[Category: Lenardo MJ]]
[[Category: Lo, Y C.]]
[[Category: Lin S-C]]
[[Category: Lu, M.]]
[[Category: Lo Y-C]]
[[Category: Myszka, D G.]]
[[Category: Lu M]]
[[Category: Rich, R L.]]
[[Category: Myszka DG]]
[[Category: Wu, H.]]
[[Category: Rich RL]]
[[Category: Yin, Q.]]
[[Category: Wu H]]
[[Category: Zheng, L.]]
[[Category: Yin Q]]
[[Category: Beta-beta-alpha]]
[[Category: Zheng L]]
[[Category: Coiled coil]]
[[Category: Cross-brace]]
[[Category: Cytoplasm]]
[[Category: Metal-binding]]
[[Category: Signaling protein]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation pathway]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep  9 08:56:46 2009''
Retrieved from "https://proteopedia.org/3hcs"