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{{Seed}}
[[Image:3gnd.jpg|left|200px]]


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==Crystal Structure of E. coli LsrF in complex with Ribulose-5-phosphate==
The line below this paragraph, containing "STRUCTURE_3gnd", creates the "Structure Box" on the page.
<StructureSection load='3gnd' size='340' side='right'caption='[[3gnd]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gnd]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GND FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5RP:RIBULOSE-5-PHOSPHATE'>5RP</scene></td></tr>
{{STRUCTURE_3gnd|  PDB=3gnd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gnd OCA], [https://pdbe.org/3gnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gnd RCSB], [https://www.ebi.ac.uk/pdbsum/3gnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gnd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LSRF_ECOLI LSRF_ECOLI] Could be involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/3gnd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gnd ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Many bacteria produce and respond to the quorum sensing signal autoinducer-2 (AI-2). Escherichia coli and Salmonella typhimurium are among the species with the lsr operon, an operon containing AI-2 transport and processing genes that are up regulated in response to AI-2. One of the Lsr proteins, LsrF, has been implicated in processing the phosphorylated form of AI-2. Here, we present the structure of LsrF, unliganded and in complex with two phospho-AI-2 analogues, ribose-5-phosphate and ribulose-5-phosphate. The crystal structure shows that LsrF is a decamer of (alphabeta)(8)-barrels that exhibit a previously unseen N-terminal domain swap and have high structural homology with aldolases that process phosphorylated sugars. Ligand binding sites and key catalytic residues are structurally conserved, strongly implicating LsrF as a class I aldolase.


===Crystal Structure of E. coli LsrF in complex with Ribulose-5-phosphate===
The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF.,Diaz Z, Xavier KB, Miller ST PLoS One. 2009 Aug 28;4(8):e6820. PMID:19714241<ref>PMID:19714241</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3gnd" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19714241}}, adds the Publication Abstract to the page
*[[Aldolase 3D structures|Aldolase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19714241 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19714241}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Escherichia coli K-12]]
3GND is a 20 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GND OCA].
[[Category: Large Structures]]
 
[[Category: Diaz ZC]]
==Reference==
[[Category: Miller ST]]
<ref group="xtra">PMID:19714241</ref><references group="xtra"/>
[[Category: Escherichia coli k-12]]
[[Category: Diaz, Z C.]]
[[Category: Miller, S T.]]
[[Category: Cytoplasm]]
[[Category: Lyase]]
[[Category: Schiff base]]
[[Category: Tim barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep  9 09:29:56 2009''

Latest revision as of 07:08, 6 September 2023

Crystal Structure of E. coli LsrF in complex with Ribulose-5-phosphate

3gnd, resolution 2.90Å

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