2kaw: Difference between revisions

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{{Seed}}
[[Image:2kaw.jpg|left|200px]]


<!--
==NMR structure of the mDvl1 PDZ domain in complex with its inhibitor==
The line below this paragraph, containing "STRUCTURE_2kaw", creates the "Structure Box" on the page.
<StructureSection load='2kaw' size='340' side='right'caption='[[2kaw]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KAW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SUZ:[(1Z)-5-FLUORO-2-METHYL-1-{4-[METHYLSULFINYL]BENZYLIDENE}-1H-INDEN-3-YL]ACETIC+ACID'>SUZ</scene></td></tr>
{{STRUCTURE_2kaw|  PDB=2kaw  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kaw OCA], [https://pdbe.org/2kaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kaw RCSB], [https://www.ebi.ac.uk/pdbsum/2kaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kaw ProSAT]</span></td></tr>
 
</table>
===NMR structure of the mDvl1 PDZ domain in complex with its inhibitor===
== Function ==
 
[https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>  
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2KAW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAW OCA].  
Check<jmol>
 
  <jmolCheckbox>
==Reference==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/2kaw_consurf.spt"</scriptWhenChecked>
<ref group="xtra">PMID:19637179</ref><references group="xtra"/>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kaw ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Lee, H J.]]
[[Category: Lee HJ]]
[[Category: Shao, Y.]]
[[Category: Shao Y]]
[[Category: Shi, D L.]]
[[Category: Shi DL]]
[[Category: Wang, N X.]]
[[Category: Wang NX]]
[[Category: Zheng, J J.]]
[[Category: Zheng JJ]]
[[Category: Cytoplasm]]
[[Category: Developmental protein]]
[[Category: Inhibitor of protein-protein interaction]]
[[Category: Nmr]]
[[Category: Pdz domain]]
[[Category: Protein structure]]
[[Category: Signaling protein]]
[[Category: Ubl conjugation]]
[[Category: Wnt signaling]]
[[Category: Wnt signaling pathway]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 09:03:52 2009''
Retrieved from "https://proteopedia.org/2kaw"