1c94: Difference between revisions

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New page: left|200px<br /><applet load="1c94" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c94, resolution 2.08Å" /> '''REVERSING THE SEQUEN...
 
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[[Image:1c94.jpg|left|200px]]<br /><applet load="1c94" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1c94, resolution 2.08&Aring;" />
'''REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.'''<br />


==Overview==
==REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.==
The question of whether a protein whose natural sequence is inverted, adopts a stable fold is still under debate. We have determined the 2. 1-A, crystal structure of the retro-GCN4 leucine zipper. In contrast to the, two-stranded helical coiled-coil GCN4 leucine zipper, the retro-leucine, zipper formed a very stable, parallel four-helix bundle, which now lends, itself to further structural and functional studies.
<StructureSection load='1c94' size='340' side='right'caption='[[1c94]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1c94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C94 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c94 OCA], [https://pdbe.org/1c94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c94 RCSB], [https://www.ebi.ac.uk/pdbsum/1c94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c94 ProSAT]</span></td></tr>
</table>


==About this Structure==
==See Also==
1C94 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C94 OCA].
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
 
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
==Reference==
__TOC__
The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure., Mittl PR, Deillon C, Sargent D, Liu N, Klauser S, Thomas RM, Gutte B, Grutter MG, Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2562-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10716989 10716989]
</StructureSection>
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Deillon, C.A.]]
[[Category: Deillon CA]]
[[Category: Gruetter, M.G.]]
[[Category: Gruetter MG]]
[[Category: Gutte, B.]]
[[Category: Gutte B]]
[[Category: Klauser, S.]]
[[Category: Klauser S]]
[[Category: Liu, N.]]
[[Category: Liu N]]
[[Category: Mittl, P.R.E.]]
[[Category: Mittl PRE]]
[[Category: Sargent, D.]]
[[Category: Sargent D]]
[[Category: Thomas, R.M.]]
[[Category: Thomas RM]]
[[Category: 4-alpha-helix-bundle]]
[[Category: peptide synthesis]]
[[Category: retro-coiled coil]]
[[Category: x-ray structure]]
 
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