3hhm: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Seed}} | {{Seed}} | ||
[[Image:3hhm. | [[Image:3hhm.png|left|200px]] | ||
<!-- | <!-- | ||
| Line 12: | Line 12: | ||
===Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin=== | ===Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin=== | ||
<!-- | |||
The line below this paragraph, {{ABSTRACT_PUBMED_19805105}}, adds the Publication Abstract to the page | |||
(as it appears on PubMed at http://www.pubmed.gov), where 19805105 is the PubMed ID number. | |||
--> | |||
{{ABSTRACT_PUBMED_19805105}} | |||
==Disease== | ==Disease== | ||
| Line 18: | Line 24: | ||
==About this Structure== | ==About this Structure== | ||
3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA]. | 3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:19805105</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | [[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | ||
| Line 42: | Line 51: | ||
[[Category: Wortmannin]] | [[Category: Wortmannin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:50:12 2009'' | ||
Revision as of 07:50, 21 October 2009
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin
Template:ABSTRACT PUBMED 19805105
Disease
Known disease associated with this structure: Breast cancer, somatic OMIM:[171834], Colorectal cancer, somatic OMIM:[171834], Gastric cancer, somatic OMIM:[171834], Hepatocellular carcinoma, somatic OMIM:[171834], Keratosis, seborrheic, somatic OMIM:[171834], Nevus, epidermal OMIM:[171834], Nonsmall cell lung cancer, somatic OMIM:[171834], Ovarian cancer, somatic OMIM:[171834]
About this Structure
3HHM is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. Epub 2009 Sep 23. PMID:19805105
Page seeded by OCA on Wed Oct 21 09:50:12 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Phosphatidylinositol-4,5-bisphosphate 3-kinase
- Amzel, L M.
- Gabelli, S B.
- Mandelker, D.
- Vogelstein, B.
- 5-triphosphate
- Atp-binding
- Disease mutation
- H1047r
- Kinase
- Nucleotide-binding
- Oncogene
- P110
- P85
- Phosphatidilynositol 3
- Pi3k
- Pi3kca
- Pik3r1
- Polymorphism
- Transferase
- Transferase/oncoprotein complex
- Wortmannin
