User:Laura Fountain/Chloride Ion Channel: Difference between revisions
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== CLIC1: A Chloride Ion Channel == | == CLIC1: A Chloride Ion Channel == | ||
< | <scene name='User:Laura_Fountain/Sandbox_1/Soluble_clic1/1'>TextToBeDisplayed</scene> | ||
CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that exist in both soluble and integral membrane forms. Purified CLIC1 can integrate into synthetic lipid bilayers forming a chloride channel with similar properties to those observed in vivo. The structure of the soluble form of CLIC1 has been determined at 1.4-A resolution, and is shown | CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that exist in both soluble and integral membrane forms. Purified CLIC1 can integrate into synthetic lipid bilayers forming a chloride channel with similar properties to those observed in vivo. The structure of the soluble form of CLIC1 has been determined at 1.4-A resolution, and is shown to the right. Integration of CLIC1 into the membrane is likely to require a major structural rearrangement, probably of the N-domain (residues 1-90), with the putative transmembrane helix arising from residues in the vicinity of the redox-active site.<ref>PMID:#11551966</ref> | ||
== About this Structure == | == About this Structure == | ||
