PTEN: Difference between revisions
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===MUTATIONS OF PTEN IN CANCER=== | ===MUTATIONS OF PTEN IN CANCER=== | ||
PTEN is a tumor suppressor protein that is mutated in several human cancers. These include glioblastomas, endometrial carcinomas, prostate carcinomas, and melanoma cases. PTEN has 403 amino acids which are separated into <scene name='Nathan_Line_sandbox/Structure/6'>two domains.</scene> The red section represents the C2 domain which allows the protein to intereact with the membrane. The phosphatase section (blue) interacts with the ligand and the phosphate head. These interactions are controled by two separate loops, the | PTEN is a tumor suppressor protein that is mutated in several human cancers. These include glioblastomas, endometrial carcinomas, prostate carcinomas, and melanoma cases. PTEN has 403 amino acids which are separated into <scene name='Nathan_Line_sandbox/Structure/6'>two domains.</scene> The red section represents the C2 domain which allows the protein to intereact with the membrane. The phosphatase section (blue) interacts with the ligand and the phosphate head. These interactions are controled by two separate loops, the <scene name='Nathan_Line_sandbox/Structure/5'>"TI" loop</scene> and the P-loop. | ||
<scene name='Nathan_Line_sandbox/Actice_site/1'>TextToBeDisplayed</scene> | <scene name='Nathan_Line_sandbox/Actice_site/1'>TextToBeDisplayed</scene> | ||
<scene name='Nathan_Line_sandbox/P_mutations/1'>TextToBeDisplayed</scene> | <scene name='Nathan_Line_sandbox/P_mutations/1'>TextToBeDisplayed</scene> | ||
