1p9x: Difference between revisions
New page: left|200px<br /><applet load="1p9x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p9x, resolution 3.40Å" /> '''THE CRYSTAL STRUCTUR... |
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[[Image:1p9x.gif|left|200px]]<br /><applet load="1p9x" size=" | [[Image:1p9x.gif|left|200px]]<br /><applet load="1p9x" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1p9x, resolution 3.40Å" /> | caption="1p9x, resolution 3.40Å" /> | ||
'''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''<br /> | '''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the ketolide telithromycin bound to the | The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains. | ||
==About this Structure== | ==About this Structure== | ||
1P9X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with TEL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1P9X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=TEL:'>TEL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Berisio, R.]] | [[Category: Berisio, R.]] | ||
[[Category: Fucini, P.]] | [[Category: Fucini, P.]] | ||
[[Category: Hansen, H | [[Category: Hansen, H A.]] | ||
[[Category: Harms, J.]] | [[Category: Harms, J.]] | ||
[[Category: Schluenzen, F.]] | [[Category: Schluenzen, F.]] | ||
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[[Category: trna]] | [[Category: trna]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:43 2008'' | ||
Revision as of 12:26, 21 February 2008
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THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC
Overview
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
About this Structure
1P9X is a Single protein structure of sequence from Deinococcus radiodurans with TEL as ligand. Full crystallographic information is available from OCA.
Reference
Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804
Page seeded by OCA on Thu Feb 21 14:26:43 2008
